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DIART ONE

Diart One 30 mg/ml, 3 ml pre-filled syringe and carton Diart One gift box with the pre-filled syringe carton and DIART® gel ice pack Lasting effects: 12 months

Highest Molecular weight hydrogel and soft-crosslinking

DIART ONE uses a proprietary technology of “soft-crosslinking” to achieve a very high molecular weight hydrogel with also a low cross-linking chemicals to Hyaluronic acid ratio of 0.1823% for highest safety.

DIART ONE efficacy has been proven in several clinical trials. For more information please visit www.reduceoakneepain.com

“Soft” cross-linking

This process gives it the overall durability while still retaining the natural viscoelastic properties of a hydrogel without becoming brittle / insoluble and losing its hydro-lubrication properties.

Cross-linking chemicals to HA
0.1823%
Low ratio, for highest safety
Diart One soft-crosslinking diagram: linear HA at 3 million dalton becomes a 325.8 million dalton network joined by double-links and mono-links

Highest Molecular Weight of Hyaluronic acid

DIART ONE showed tolerability and safety in a single injection for 6 months in subjects with knee OA grades II to IV Kellgren and Lawrence classification1

DIART ONE showed:-

  • A sustained tolerability and safety of treatment with pain reduction of 60.58% by 3 months
  • Gradually and significantly decreased in WOMAC pain score across the visits by month 3

References:

  1. Nazar Vadzyuk Postmarketing, Prospective, Multicentre, Single-Arm Study of Subjects Who Receive an Injection of a Medical Device Based on Hyaluronic Acid: Clinical Study Report. World Science. 1(83). doi: 10.31435/rsglobal_ws/30032024/8127
Knee (KL grade)1234
Left %7.336.416.47.3
Right %7.332.727.31.8
Radar chart of SF-36 quality of life scores before treatment and at 3, 6 and 12 months: every domain, including physical functioning, pain, social functioning and emotional wellbeing, improves after injection
The SF-36 scores typically range from 0 to 100, with higher scores indicating better health status.

Clinically significant reduction in knee pain with psychological improvements before and after injection of HA in knee OA in 12 months study2

In this first of a kind study, one injection of DIART ONE :-

  • was able to reduce VAS pain score significantly at 6 months for (p<0.000) and 12 months (p<0.000)
  • Significant psychological improvements of depression and anxiety (p<0.01) and Short Form Health Survey 36 (SF-36) quality of life.

References:

  1. Vincenzo Rania, et al. (2024) Efficacy and Safety of Intraarticular Therapy with Cross-Linked Hyaluronic Acid in Patients with Knee Osteoarthritis. doi: 10.20944/preprints202411.2249.v1

Ice and Heat Wrap

Easy and comfortable pain management for post injection & pain.

Contains food grade gel that serves as a coolant and can be applied to the knee, shoulder, elbow, ankle and soft tissues.

Ice and Heat Wrap gel pack worn on the knee with wide breathable straps, a close-up of its plush underside, and the full pack front
The DIART ONE set: outer box, DIART ONE syringe carton and the DIART® gel ice pack
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